This project investigates how VR technology can address accessibility challenges for individuals with locomotor disabilities, particularly those with single-handed mobility issues. It underscores the global need to cater to this demographic and explores transformative potential in enhancing accessibility of VR. The project involves designing and prototyping novel VR interactions for one-handed users on devices like Meta Quest 2 or Quest Pro, aiming to create inclusive experiences and advance digital equity. We tested existing interactions for sketching in VR, like Gravity Sketch, and evaluated them. Based on that, we conceptualized and designed hand-tracking interactions for one-handed sketching, moving away from dual-controller setups, with a focus on intuitive techniques for VR sketching. These include interactions for drawing, selecting tools, editing tools, and selecting colors. Later, these interactions were tested and validated but indicated the need for further enhancement as well.